Article
Frequent reduction or absence of detection of the JAK2-mutated clone in JAK2V617F-positive patients within the first years of hydroxyurea therapy.
Haematologica - 1 Nov 2008
Girodon François, Schaeffer Céline, Cleyrat Cédric, Mounier Morgane, Lafont Ingrid, Santos Frédéric Dos, Duval Aurélie, Vidal Aurélie, Maynadié Marc, Hermouet Sylvie
Abstract excerpt
We analyzed the effect of hydroxyurea on the JAK2V617F allelic ratio (%JAK2V617F), measured in purified blood granulocytes, of patients with polycythemia vera and essential thrombocythemia. Thirty-six patients were examined sequentially prior to and after start of hydroxy-urea therapy (8 polycythemia vera, 17 essential thrombocythemia), or while remaining untreated (2 polycythemia vera, 9 essential...
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