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Article

Impact of JAK2(V617F) mutation status on treatment response to anagrelide in essential thrombocythemia: an observational, hypothesis-generating study.

Drug design, development and therapy - 1 Jan 2015

Cascavilla Nicola, De Stefano Valerio, Pane Fabrizio, Pancrazzi Alessandro, Iurlo Alessandra, Gobbi Marco, Palandri Francesca, Specchia Giorgina, Liberati A Marina, D'Adda Mariella, Gaidano Gianluca, Fjerza Rajmonda, Achenbach Heinrich, Smith Jonathan, Wilde Paul, Vannucchi Alessandro M

Abstract excerpt

A JAK2(V617F) mutation is found in approximately 55% of patients with essential thrombocythemia (ET), and represents a key World Health Organization diagnostic criterion. This hypothesis-generating study (NCT01352585) explored the impact of JAK2(V617F) mutation status on treatment response to anagrelide in patients with ET who were intolerant/refractory to their current cytoreductive therapy. The primary...

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Identifiers

PMID: 26028965
DOI: 10.2147/DDDT.S79576
PMCID: PMC4441358

Genes

JAK2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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