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Meiosis interrupted: the genetics of female infertility via meiotic failure

10 Nov 2020

Abstract excerpt

Idiopathic or 'unexplained' infertility represents as many as 30% of infertility cases worldwide. Conception, implantation, and term delivery of developmentally healthy infants require chromosomally normal (euploid) eggs and sperm. The crux of euploid egg production is error-free meiosis. Pathologic genetic variants dysregulate meiotic processes that occur during prophase I, meiotic resumption, chromosome...

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PMID: 33170803
DOI: 10.1530/rep-20-0422

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