Article
Empirical versus theoretical power and type I error (false-positive) rates estimated from real murine aging research data.
Cell reports - 17 Aug 2021
Alfaras Irene, Ejima Keisuke, Vieira Ligo Teixeira Camila, Di Germanio Clara, Mitchell Sarah J, Hamilton Samuel, Ferrucci Luigi, Price Nathan L, Allison David B, Bernier Michel, de Cabo Rafael
Abstract excerpt
We assess the degree of phenotypic variation in a cohort of 24-month-old male C57BL/6 mice. Because murine studies often use small sample sizes, if the commonly relied upon assumption of a normal distribution of residuals is not met, it may inflate type I error rates. In this study, 3-20 mice are resampled from the empirical distributions of 376 mice to create plasmodes, an approach for computing type I error...
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