Article
Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice.
Nature communications - 11 Nov 2022
Xie Kan, Fuchs Helmut, Scifo Enzo, Liu Dan, Aziz Ahmad, Aguilar-Pimentel Juan Antonio, Amarie Oana Veronica, Becker Lore, da Silva-Buttkus Patricia, Calzada-Wack Julia, Cho Yi-Li, Deng Yushuang, Edwards A Cole, Garrett Lillian, Georgopoulou Christina, Gerlini Raffaele, Hölter Sabine M, Klein-Rodewald Tanja, Kramer Michael, Leuchtenberger Stefanie, Lountzi Dimitra, Mayer-Kuckuk Phillip, Nover Lena L, Oestereicher Manuela A, Overkott Clemens, Pearson Brandon L, Rathkolb Birgit, Rozman Jan, Russ Jenny, Schaaf Kristina, Spielmann Nadine, Sanz-Moreno Adrián, Stoeger Claudia, Treise Irina, Bano Daniele, Busch Dirk H, Graw Jochen, Klingenspor Martin, Klopstock Thomas, Mock Beverly A, Salomoni Paolo, Schmidt-Weber Carsten, Weiergräber Marco, Wolf Eckhard, Wurst Wolfgang, Gailus-Durner Valérie, Breteler Monique M B, Hrabě de Angelis Martin, Ehninger Dan
Abstract excerpt
Current concepts regarding the biology of aging are primarily based on studies aimed at identifying factors regulating lifespan. However, lifespan as a sole proxy measure for aging can be of limited value because it may be restricted by specific pathologies. Here, we employ large-scale phenotyping to analyze hundreds of markers in aging male C57BL/6J mice. For each phenotype, we establish lifetime profiles to...
Read the complete abstract on PubMed