Article
A multi-lab experimental assessment reveals that replicability can be improved by using empirical estimates of genotype-by-lab interaction.
PLoS biology - 1 May 2023
Jaljuli Iman, Kafkafi Neri, Giladi Eliezer, Golani Ilan, Gozes Illana, Chesler Elissa J, Bogue Molly A, Benjamini Yoav
Abstract excerpt
The utility of mouse and rat studies critically depends on their replicability in other laboratories. A widely advocated approach to improving replicability is through the rigorous control of predefined animal or experimental conditions, known as standardization. However, this approach limits the generalizability of the findings to only to the standardized conditions and is a potential cause rather than solution...
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