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Article

A Reassessment of Genes Modulating Aging in Mice Using Demographic Measurements of the Rate of Aging.

Genetics - 1 Apr 2018

Pedro de Magalhães João, Thompson Louise, de Lima Izabella, Gaskill Dale, Li Xiaoyu, Thornton Daniel, Yang Chenhao, Palmer Daniel

Abstract excerpt

Many studies have reported genetic interventions that have an effect on mouse life span; however, it is crucial to discriminate between manipulations of aging and aging-independent causes of life extension. Here, we used the Gompertz equation to determine whether previously reported aging-related mouse genes statistically affect the demographic rate of aging. Of 30 genetic manipulations previously reported to...

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Identifiers

PMID: 29444805
DOI: 10.1534/genetics.118.300821
PMCID: PMC5887152

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