Article
HLA engineering of human pluripotent stem cells.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Jun 2013
Riolobos Laura, Hirata Roli K, Turtle Cameron J, Wang Pei-Rong, Gornalusse German G, Zavajlevski Maja, Riddell Stanley R, Russell David W
Abstract excerpt
The clinical use of human pluripotent stem cells and their derivatives is limited by the rejection of transplanted cells due to differences in their human leukocyte antigen (HLA) genes. This has led to the proposed use of histocompatible, patient-specific stem cells; however, the preparation of many different stem cell lines for clinical use is a daunting task. Here, we develop two distinct genetic engineering...
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