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Article

Induction of Gastric Cancer by Successive Oncogenic Activation in the Corpus.

Gastroenterology - 1 Dec 2021

Douchi Daisuke, Yamamura Akihiro, Matsuo Junichi, Melissa Lim Yi Hui, Nuttonmanit Napat, Shimura Mitsuhiro, Suda Kazuto, Chen Sabirah, Pang ShuChin, Kohu Kazuyoshi, Abe Takaya, Shioi Go, Kim Guowei, Shabbir Asim, Srivastava Supriya, Unno Michiaki, Bok-Yan So Jimmy, Teh Ming, Yeoh Khay Guan, Chuang Linda Shyue Huey, Ito Yoshiaki

Abstract excerpt

BACKGROUND & AIMS: Metaplasia and dysplasia in the corpus are reportedly derived from de-differentiation of chief cells. However, the cellular origin of metaplasia and cancer remained uncertain. Therefore, we investigated whether pepsinogen C (PGC) transcript-expressing cells represent the cellular origin of metaplasia and cancer using a novel Pgc-specific CreERT2 recombinase mouse model. METHODS: We generated a...

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Identifiers

PMID: 34391772
DOI: 10.1053/j.gastro.2021.08.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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