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Relationship between p63 and p53 expression in Merkel cell carcinoma and corresponding abnormalities in TP63 and TP53: a study and a proposal.

Human pathology - 1 Nov 2021

DeCoste Ryan C, Carter Michael D, Pasternak Sylvia, Fleming Kirsten E, Gaston Daniel, Legge Alexandra, Ly Thai Yen, Walsh Noreen M

Abstract excerpt

Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine carcinoma. Oncogenesis occurs via Merkel cell polyomavirus-mediated (MCPyV+) and/or ultraviolet radiation-associated (MCPyV-) pathways. Advanced clinical stage and an MCPyV- status are important adverse prognostic indicators. There is mounting evidence that p63 expression is a negative prognostic indicator in MCC and that it correlates...

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PMID: 34391748
DOI: 10.1016/j.humpath.2021.08.003

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