SIRT1 Gene SNP rs932658 Is Associated With Medication-Related Osteonecrosis of the Jaw.

doi:10.1002/jbmr.4185

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Article

SIRT1 Gene SNP rs932658 Is Associated With Medication-Related Osteonecrosis of the Jaw.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Feb 2021

Yang Guang, Collins Joseph M, Rafiee Roya, Singh Sonal, Langaee Taimour, McDonough Caitrin W, Holliday L Shannon, Wang Danxin, Lamba Jatinder K, Kim Young Sick, Pelliccioni Gian Andrea, Vaszilko Mihaly, Kosa Janos P, Balla Bernadett, Lakatos Peter A, Katz Joseph, Moreb Jan, Gong Yan

Abstract excerpt

Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious adverse drug reaction. Our previous whole-exome sequencing study found SIRT1 intronic region single-nucleotide polymorphism (SNP) rs7896005 to be associated with MRONJ in cancer patients treated with intravenous (iv) bisphosphonates (BPs). This study aimed to identify causal variants for this association. In silico analyses identified three...

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PMID: 32967053
DOI: 10.1002/jbmr.4185
PMCID: PMC8733933

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