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Article

Genetic Background of Medication-Related Osteonecrosis of the Jaw: Current Evidence and Future Perspectives.

International journal of molecular sciences - 29 Sept 2024

Bojtor Bence, Balla Bernadett, Vaszilko Mihaly, Szentpeteri Szofia, Putz Zsuzsanna, Kosa Janos P, Lakatos Peter

Abstract excerpt

Medication-related osteonecrosis of the jaw (MRONJ) is a rare side effect of antiresorptive drugs that significantly hinders the quality of life of affected patients. The disease develops in the presence of a combination of factors. Important pathogenetic factors include inflammation, inhibition of bone remodeling, or genetic predisposition. Since the first description of this rare side effect in 2003, a growing...

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Identifiers

PMID: 39408816
DOI: 10.3390/ijms251910488
PMCID: PMC11477157

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