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Article

SIRT1/HERC4 Locus Associated With Bisphosphonate-Induced Osteonecrosis of the Jaw: An Exome-Wide Association Analysis.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jan 2018

Yang Guang, Hamadeh Issam S, Katz Joseph, Riva Alberto, Lakatos Peter, Balla Bernadett, Kosa Janos, Vaszilko Mihaly, Pelliccioni Gian Andrea, Davis Noa, Langaee Taimour Y, Moreb Jan S, Gong Yan

Abstract excerpt

Osteonecrosis of the jaw (ONJ) is a rare, but serious drug side effect, mainly associated with the use of intravenous (iv) bisphosphonates (BPs). The purpose of this study was to identify genetic variants associated with ONJ in patients of European ancestry treated with iv BPs using whole-exome sequencing (WES). The WES phase 1 included 44 multiple myeloma patients (22 ONJ cases and 22 controls) and WES phase 2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28856724
DOI: 10.1002/jbmr.3285

Genes

SIRT1
HERC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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