Tumor protein 53 mutations and inherited cancer: beyond Li-Fraumeni syndrome.

doi:10.1097/CCO.0b013e328333bf00

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Article

Tumor protein 53 mutations and inherited cancer: beyond Li-Fraumeni syndrome.

Current opinion in oncology - 1 Jan 2010

Palmero Edenir I, Achatz Maria Iw, Ashton-Prolla Patricia, Olivier Magali, Hainaut Pierre

Abstract excerpt

PURPOSE OF REVIEW: Germline TP53 (tumor protein 53) mutations are the molecular basis of a complex cancer predisposition syndrome, the Li-Fraumeni syndrome. The present review discusses the diversity of tumor patterns in TP53 mutation carriers, focusing on molecular factors that may explain familial and individual differences, such as genotype/phenotype correlations, genetic modifiers and genetic anticipation....

Topics

Genetic Predisposition to Disease
Germ-Line Mutation
Humans
Li-Fraumeni Syndrome
Neoplasms
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 19952748
DOI: 10.1097/CCO.0b013e328333bf00

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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