Article
TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes.
Oncogene - 2 Apr 2007
Petitjean A, Achatz M I W, Borresen-Dale A L, Hainaut P, Olivier M
Abstract excerpt
A large amount of data is available on the functional impact of missense mutations in TP53 and on mutation patterns in many different cancers. New data on mutant p53 protein function, cancer phenotype and prognosis have recently been integrated in the International Agency for Research on Cancer TP53 database (http://www-p53.iarc.fr/). Based on these data, we summarize here current knowledge on the respective...
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