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Molecular profiling reveals primary mesothelioma cell lines recapitulate human disease

19 Feb 2016

Abstract excerpt

Malignant mesothelioma (MM) is an aggressive, fatal tumor strongly associated with asbestos exposure. There is an urgent need to improve MM patient outcomes and this requires functionally validated pre-clinical models. Mesothelioma-derived cell lines provide an essential and relatively robust tool and remain among the most widely used systems for candidate drug evaluation. Although a number of cell lines are...

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PMID: 26891694
DOI: 10.1038/cdd.2015.165

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