Article
An imputed whole-genome sequence-based GWAS approach pinpoints causal mutations for complex traits in a specific swine population.
Science China. Life sciences - 1 Apr 2022
Yan Guorong, Liu Xianxian, Xiao Shijun, Xin Wenshui, Xu Wenwu, Li Yiping, Huang Tao, Qin Jiangtao, Xie Lei, Ma Junwu, Zhang Zhiyan, Huang Lusheng
Abstract excerpt
Sequencing-based genome-wide association studies (GWAS) have facilitated the identification of causal associations between genetic variants and traits in diverse species. However, it is cost-prohibitive for the majority of research groups to sequence a large number of samples. Here, we carried out genotype imputation to increase the density of single nucleotide polymorphisms in a large-scale Swine F2 population...
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