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Article

Large scale sequence-based screen for recessive variants allows for identification and monitoring of rare deleterious variants in pigs.

PLoS genetics - 1 Jan 2024

Boshove Anne, Derks Martijn F L, Sevillano Claudia A, Lopes Marcos S, van Son Maren, Knol Egbert F, Dibbits Bert, Harlizius Barbara

Abstract excerpt

Most deleterious variants are recessive and segregate at relatively low frequency. Therefore, high sample sizes are required to identify these variants. In this study we report a large-scale sequence based genome-wide association study (GWAS) in pigs, with a total of 120,000 Large White and 80,000 Synthetic breed animals imputed to sequence using a reference population of approximately 1,100 whole genome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38198533
DOI: 10.1371/journal.pgen.1011034
PMCID: PMC10805306

Genes

CCND2
CDHR2
MC4R
OBSL1

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