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Article

Specific PIWI-Interacting RNAs and Related Small Noncoding RNAs Are Associated With Ovarian Aging in Ames Dwarf (df/df) Mice.

The journals of gerontology. Series A, Biological sciences and medical sciences - 13 Aug 2021

Dhahbi Joseph M, Chen Joe W, Bhupathy Supriya, Atamna Hani, Cavalcante Marcelo B, Saccon Tatiana D, Nunes Allancer D C, Mason Jeffrey B, Schneider Augusto, Masternak Michal M

Abstract excerpt

The Ames dwarf (df/df) mouse is a well-established model for delayed aging. MicroRNAs (miRNAs), the most studied small noncoding RNAs (sncRNAs), may regulate ovarian aging to maintain a younger ovarian phenotype in df/df mice. In this study, we profile other types of ovarian sncRNAs, PIWI-interacting RNAs (piRNAs) and piRNA-like RNAs (piLRNAs), in young and aged df/df and normal mice. Half of the piRNAs derive...

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Identifiers

PMID: 34387333
DOI: 10.1093/gerona/glab113
PMCID: PMC8361361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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