Article
Local versus systemic control of bone and skeletal muscle mass by components of the transforming growth factor-β signaling pathway.
Proceedings of the National Academy of Sciences of the United States of America - 17 Aug 2021
Liu Yewei, Lehar Adam, Rydzik Renata, Chandok Harshpreet, Lee Yun-Sil, Youngstrom Daniel W, George Joshy, Matzuk Martin M, Germain-Lee Emily L, Lee Se-Jin
Abstract excerpt
Skeletal muscle and bone homeostasis are regulated by members of the myostatin/GDF-11/activin branch of the transforming growth factor-β superfamily, which share many regulatory components, including inhibitory extracellular binding proteins and receptors that mediate signaling. Here, we present the results of genetic studies demonstrating a critical role for the binding protein follistatin (FST) in regulating...
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