Article
Female infertility and disrupted angiogenesis are actions of specific follistatin isoforms.
Molecular endocrinology (Baltimore, Md.) - 1 Feb 2008
Lin Shyr-Yeu, Craythorn Rebecca G, O'Connor Anne E, Matzuk Martin M, Girling Jane E, Morrison John R, de Kretser David M
Abstract excerpt
The circulating and tissue-bound forms of follistatin (FST315 and FST288, respectively) modulate the actions of activins. FST knockout (KO/null) mice, lacking both isoforms, die perinatally with defects in lung, skin, and the musculoskeletal system. Using constructs of the human FST gene engineered to enable expression of each isoform under the control of natural regulatory elements, transgenic mouse lines were...
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