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Article

Poor T-cell receptor β repertoire diversity early posttransplant for severe combined immunodeficiency predicts failure of immune reconstitution

9 Aug 2021

Abstract excerpt

Background Development of a diverse T-cell receptor β ( TRB ) repertoire is associated with immune recovery following hematopoietic cell transplantation (HCT) for severe combined immunodeficiency (SCID). High-throughput sequencing of the TRB repertoire allows evaluation of clonotype dynamics during immune reconstitution. Objectives We investigated whether longitudinal analysis of the TRB repertoire would...

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Share to Hematopoietic Stem Cell Transplantation
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PMID: 34384841
DOI: 10.1016/j.jaci.2021.07.029

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