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Article

T cell dynamics and response of the microbiota after gene therapy to treat X-linked severe combined immunodeficiency

16 Sept 2018

Abstract excerpt

BACKGROUND: Mutation of the IL2RG gene results in a form of severe combined immune deficiency (SCID-X1), which has been treated successfully with hematopoietic stem cell gene therapy. SCID-X1 gene therapy results in reconstitution of the previously lacking T cell compartment, allowing analysis of the roles of T cell immunity in humans by comparing before and after gene correction. METHODS: Here we interrogate T...

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PMID: 30261899
DOI: 10.1186/s13073-018-0580-z

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