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Article

Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice.

Nature - 30 Aug 2012

Tsai Peter T, Hull Court, Chu YunXiang, Greene-Colozzi Emily, Sadowski Abbey R, Leech Jarrett M, Steinberg Jason, Crawley Jacqueline N, Regehr Wade G, Sahin Mustafa

Abstract excerpt

Autism spectrum disorders (ASDs) are highly prevalent neurodevelopmental disorders, but the underlying pathogenesis remains poorly understood. Recent studies have implicated the cerebellum in these disorders, with post-mortem studies in ASD patients showing cerebellar Purkinje cell (PC) loss, and isolated cerebellar injury has been associated with a higher incidence of ASDs. However, the extent of cerebellar...

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Identifiers

PMID: 22763451
DOI: 10.1038/nature11310
PMCID: PMC3615424

Genes

TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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