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Article

Penetrance of Breast Cancer Susceptibility Genes From the eMERGE III Network.

JNCI cancer spectrum - 1 Aug 2021

Fan Xiao, Wynn Julia, Shang Ning, Liu Cong, Fedotov Alexander, Hallquist Miranda L G, Buchanan Adam H, Williams Marc S, Smith Maureen E, Hoell Christin, Rasmussen-Torvik Laura J, Peterson Josh F, Wiesner Georgia L, Murad Andrea M, Jarvik Gail P, Gordon Adam S, Rosenthal Elisabeth A, Stanaway Ian B, Crosslin David R, Larson Eric B, Leppig Kathleen A, Henrikson Nora B, Williams Janet L, Li Rongling, Hebbring Scott, Weng Chunhua, Shen Yufeng, Crew Katherine D, Chung Wendy K

Abstract excerpt

Background: Unbiased estimates of penetrance are challenging but critically important to make informed choices about strategies for risk management through increased surveillance and risk-reducing interventions. Methods: We studied the penetrance and clinical outcomes of 7 breast cancer susceptibility genes (BRCA1, BRCA2, TP53, CHEK2, ATM, PALB2, and PTEN) in almost 13 458 participants unselected for personal or...

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Source

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Identifiers

PMID: 34377931
DOI: 10.1093/jncics/pkab044
PMCID: PMC8346699

Genes

ATM
CHEK2
PALB2
BRCA1
BRCA2
PTEN
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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