Plasma Metabolic Phenotypes of HPV-Associated versus Smoking-Associated Head and Neck Cancer and Patient Survival.

doi:10.1158/1055-9965.EPI-21-0576

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Article

Plasma Metabolic Phenotypes of HPV-Associated versus Smoking-Associated Head and Neck Cancer and Patient Survival.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2021

Eldridge Ronald C, Uppal Karan, Hayes D Neil, Smith M Ryan, Hu Xin, Qin Zhaohui S, Beitler Jonathan J, Miller Andrew H, Wommack Evanthia C, Higgins Kristin A, Shin Dong M, Ulrich Bryan, Qian David C, Saba Nabil F, Bruner Deborah W, Jones Dean P, Xiao Canhua

Abstract excerpt

BACKGROUND: Metabolic differences between human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) and smoking-associated HNSCC may partially explain differences in prognosis. The former relies on mitochondrial oxidative phosphorylation (OXPHOS) while the latter relies on glycolysis. These differences have not been studied in blood. METHODS: We extracted metabolites using untargeted...

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Identifiers

PMID: 34376485
DOI: 10.1158/1055-9965.EPI-21-0576
PMCID: PMC8492502

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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