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High expression of oxidative phosphorylation genes predicts improved survival in squamous cell carcinomas of the head and neck and lung

14 Apr 2020

Abstract excerpt

Mitochondrial activity is a critical component of tumor metabolism, with profound implications for tumorigenesis and treatment response. We analyzed clinical, genomic and expression data from patients with oral cavity squamous cell carcinoma (OCSCC) in order to map metabologenomic events which may correlate with clinical outcomes and identified nuclear genes involved in oxidative phosphorylation and glycolysis...

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PMID: 32286489
DOI: 10.1038/s41598-020-63448-z

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