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Article

Loss of Lysosomal Proteins Progranulin and Prosaposin Associated with Increased Neurofibrillary Tangle Development in Alzheimer Disease.

Journal of neuropathology and experimental neurology - 10 Sept 2021

Mendsaikhan Anarmaa, Tooyama Ikuo, Serrano Geidy E, Beach Thomas G, Walker Douglas G

Abstract excerpt

Alzheimer disease (AD) is a progressive neurodegenerative disease causing cognitive decline in the aging population. To develop disease-modifying treatments, understanding the mechanisms behind the pathology is important, which should include observations using human brain samples. We reported previously on the association of lysosomal proteins progranulin (PGRN) and prosaposin (PSAP) with amyloid plaques in...

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Identifiers

PMID: 34374777
DOI: 10.1093/jnen/nlab056
PMCID: PMC8433593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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