Article
Exploring the enigmatic association between PNLIP variants and risk of chronic pancreatitis in a large Chinese cohort.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Jun 2024
Cassidy Brett M, Jiang Fei, Lin Jianguo, Chen Jian-Min, Curry Grace E, Ma Guo-Xiu, Wilhelm Steven J, Deng Shun-Jiang, Zhu Guoying, Liao Zhuan, Lowe Mark E, Xiao Xunjun K, Zou Wen-Bin
Abstract excerpt
BACKGROUND & AIMS: Protease-sensitive PNLIP variants were recently associated with chronic pancreatitis (CP) in European populations. The pathological mechanism yet remains elusive. Herein, we performed a comprehensive genetic and functional analysis of PNLIP variants found in a large Chinese cohort, aiming to further unravel the enigmatic association of PNLIP variants with CP. METHODS: All coding and flanking...
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