Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeling protease-sensitive human pancreatic lipase mutations in the mouse ortholog.

The Journal of biological chemistry - 1 Oct 2024

Hoffka Gyula, Mhana Samara, Vas Marcell, Toldi Vanda, Mótyán János András, Tőzsér József, Szabó András

Abstract excerpt

Pancreatic lipase (PNLIP) is the major lipolytic enzyme secreted by the pancreas. A recent study identified human PNLIP variants P245A, I265R, F300L, S304F, and F314L in European cohorts with chronic pancreatitis. Functional analyses indicated that the variants were normally secreted but exhibited reduced stability when exposed to pancreatic proteases. Proteolysis of the PNLIP variants yielded an intact...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acyltransferases
Share to Chymotrypsin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Stability

Share to Lipase

Share to Pancreatitis, Chronic

Share to Protein Domains

Share to Proteolysis

Share to Trypsin

Source

Open in PubMed Open full text

Identifiers

PMID: 39265662
DOI: 10.1016/j.jbc.2024.107763
PMCID: PMC11489347

Genes

PNLIP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling protease-sensitive human pancreatic lipase mutations in the mouse ortholog.PMID 39265662Read ↗

Exploring the enigmatic association between PNLIP variants and risk of chronic pancreatitis in a large Chinese cohort.Semantic proximity Read ↗

Missense PNLIP mutations impeding pancreatic lipase secretion cause protein misfolding and endoplasmic reticulum stress.Semantic proximity Read ↗

Identification of protease-sensitive but not misfolding PNLIP variants in familial and hereditary pancreatitis.Semantic proximity Read ↗

Diverse Misfolding Mutant Digestive Enzymes Cause Chronic Pancreatitis Through Common Pathways.Semantic proximity Read ↗

Human CPA1 mutation causes digestive enzyme misfolding and chronic pancreatitis in mice.Semantic proximity Read ↗

Protease-Sensitive Pancreatic Lipase Variants Are Associated With Early Onset Chronic PancreatitisSemantic proximity Read ↗

Mouse model suggests limited role for human mesotrypsin in pancreatitis.Semantic proximity Read ↗

Functional characterization of furin-mediated lipoprotein lipase cleavage.Semantic proximity Read ↗

Complete Rescue of Lipoprotein Lipase–Deficient Mice by Somatic Gene Transfer of the Naturally Occurring LPLS447XBeneficial MutationSemantic proximity Read ↗

Obese yeast: triglyceride lipolysis is functionally conserved from mammals to yeast.Semantic proximity Read ↗

Novel p.G250A Mutation Associated with Chronic Pancreatitis Highlights Misfolding-Prone Region in Carboxypeptidase A1 (CPA1).Semantic proximity Read ↗

Induced lipase mutations in the mouse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.