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Article

A Carboxyl Ester Lipase (CEL) Mutant Causes Chronic Pancreatitis by Forming Intracellular Aggregates That Activate Apoptosis.

The Journal of biological chemistry - 28 Oct 2016

Xiao Xunjun, Jones Gabrielle, Sevilla Wednesday A, Stolz Donna B, Magee Kelsey E, Haughney Margaret, Mukherjee Amitava, Wang Yan, Lowe Mark E

Abstract excerpt

Patients with chronic pancreatitis (CP) frequently have genetic risk factors for disease. Many of the identified genes have been connected to trypsinogen activation or trypsin inactivation. The description of CP in patients with mutations in the variable number of tandem repeat (VNTR) domain of carboxyl ester lipase (CEL) presents an opportunity to study the pathogenesis of CP independently of trypsin pathways....

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Identifiers

PMID: 27650499
DOI: 10.1074/jbc.M116.734384
PMCID: PMC5087739

Genes

CEL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

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A Carboxyl Ester Lipase (CEL) Mutant Causes Chronic Pancreatitis by Forming Intracellular Aggregates That Activate Apoptosis.PMID 27650499Read ↗

The position of single-base deletions in the VNTR sequence of the carboxyl ester lipase (CEL) gene determines proteotoxicity.Semantic proximity Read ↗

Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY): a protein misfolding disease.Semantic proximity Read ↗

The position of single-base deletions in the VNTR sequence of the carboxyl ester lipase ( <i>CEL</i> ) gene determines pathogenicitySemantic proximity Read ↗

Single nucleotide polymorphisms in CEL-HYB1 increase risk for chronic pancreatitis through proteotoxic misfolding.Semantic proximity Read ↗

The role of the carboxyl ester lipase (CEL) gene in pancreatic disease.Semantic proximity Read ↗

Chronic pancreatitis: an update on genetic risk factors.Semantic proximity Read ↗

Exploring the enigmatic association between PNLIP variants and risk of chronic pancreatitis in a large Chinese cohort.Semantic proximity Read ↗

A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis.Semantic proximity Read ↗

The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice.Semantic proximity Read ↗

Missense PNLIP mutations impeding pancreatic lipase secretion cause protein misfolding and endoplasmic reticulum stress.Semantic proximity Read ↗

Pathogenic Carboxyl Ester Lipase (CEL) Variants Interact with the Normal CEL Protein in Pancreatic Cells.Semantic proximity Read ↗

Common single-base insertions in the VNTR of the carboxyl ester lipase (CEL) gene are benign and also likely to arise somatically in the exocrine pancreas.Semantic proximity Read ↗

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