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Article

AlphaB-crystallin, a small heat-shock protein, prevents the amyloid fibril growth of an amyloid beta-peptide and beta2-microglobulin.

The Biochemical journal - 15 Dec 2005

Raman Bakthisaran, Ban Tadato, Sakai Miyo, Pasta Saloni Y, Ramakrishna Tangirala, Naiki Hironobu, Goto Yuji, Rao Ch Mohan

Abstract excerpt

AlphaB-crystallin, a small heat-shock protein, exhibits molecular chaperone activity. We have studied the effect of alphaB-crystallin on the fibril growth of the Abeta (amyloid beta)-peptides Abeta-(1-40) and Abeta-(1-42). alphaB-crystallin, but not BSA or hen egg-white lysozyme, prevented the fibril growth of Abeta-(1-40), as revealed by thioflavin T binding, total internal reflection fluorescence microscopy and...

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Identifiers

PMID: 16053447
DOI: 10.1042/BJ20050339
PMCID: PMC1316297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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