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Article

Current Knowledge of Endolysosomal and Autophagy Defects in Hereditary Spastic Paraplegia

2 Jul 2021

Abstract excerpt

Hereditary spastic paraplegia (HSP) refers to a group of neurological disorders involving the degeneration of motor neurons. Due to their clinical and genetic heterogeneity, finding common effective therapeutics is difficult. Therefore, a better understanding of the common pathological mechanisms is necessary. The role of several HSP genes/proteins is linked to the endolysosomal and autophagic pathways,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34359848
DOI: 10.3390/cells10071678

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