Article

Rhinovirus C replication is associated with the endoplasmic reticulum and triggers cytopathic effects in an <i>in vitro</i> model of human airway epithelium

2021-04-17

Abstract excerpt

The clinical impact of rhinovirus C (RV-C) is well-documented; yet the viral life cycle remains poorly defined. Thus, we characterized RV-C15 replication at the single-cell level and its impact on the human airway epithelium (HAE) using a physiologically-relevant in vitro model. RV-C15 replication was restricted to ciliated cells where viral RNA levels peaked at 12 hours post-infection (hpi), correlating with ele...

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Literature Corpus work: 8665c08a-bf04-5a61-9b93-c4ebc93ee25a
DOI: 10.1101/2021.04.16.440244

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