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Article

Identifying Oncogenic Missense Single Nucleotide Polymorphisms in Human SAT1 Gene Using Computational Algorithms and Molecular Dynamics Tools.

Cancer reports (Hoboken, N.J.) - 1 Jul 2024

Mozibullah Md, Khatun Marina, Sikder Md Asaduzzaman, Islam Mohammod Johirul, Sharmin Mehbuba

Abstract excerpt

BACKGROUND: The human SAT1 gene encodes spermidine/spermine N1-acetyltransferase 1 (SSAT1), a regulatory biological catalyst of polyamine catabolism. Numerous essential biological processes, such as cellular proliferation, differentiation, and survival, depend on polyamines like spermidine and spermine. Thus, SSAT1 is involved in key cellular activities such as proliferation and survival of cells and mediates...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39041636
DOI: 10.1002/cnr2.2130
PMCID: PMC11264109

Genes

SAT1

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