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Article

Computational Insights into the Deleterious Impacts of Missense Variants on N-Acetyl-d-glucosamine Kinase Structure and Function.

International journal of molecular sciences - 28 Jul 2021

Dash Raju, Mitra Sarmistha, Munni Yeasmin Akter, Choi Ho Jin, Ali Md Chayan, Barua Largess, Jang Tae Jung, Moon Il Soo

Abstract excerpt

An enzyme of the mammalian amino-sugar metabolism pathway, N-acetylglucosamine kinase (NAGK), that synthesizes N-acetylglucosamine (GlcNAc)-6-phosphate, is reported to promote dynein functions during mitosis, axonal and dendritic growth, cell migration, and selective autophagy, which all are unrelated to its enzyme activity. As non-enzymatic structural functions can be altered by genetic variation, we made an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Phosphotransferases (Alcohol Group Acceptor)

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Identifiers

PMID: 34360815
DOI: 10.3390/ijms22158048
PMCID: PMC8347710

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