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Article

Analysis of damaging non-synonymous SNPs in GPx1 gene associated with the progression of diverse cancers through a comprehensive in silico approach.

Scientific reports - 20 Nov 2024

Iqbal Muhammad Waleed, Shahab Muhammad, Zheng Guojun, Sun Xinxiao, Yuan Qipeng, Almaary Khalid S, Wondmie Gezahign Fentahun, Bourhia Mohammed

Abstract excerpt

Glutathione Peroxidase 1 (GPx1) gene has been reported for its role in cellular redox homeostasis, and the dysregulation of its expression is linked with the progression of diverse cancers. Non-synonymous single nucleotide polymorphism (nsSNPs) have been emerged as the crucial factors, playing their role in GPx1 overexpression. To understand the deleterious mutational effects on the structure and function of GPx1...

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Identifiers

PMID: 39562776
DOI: 10.1038/s41598-024-78232-6
PMCID: PMC11577101

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