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Sustained high prevalence of multiple antimalarial drug resistance markers in Uganda in 2023-2024.

Antimicrobial agents and chemotherapy - 5 Aug 2026

Katairo Thomas, Asua Victor, Semakuba Francis D, Nsengimaana Bienvenu, Kiyaga Shahiid, Hathaway Nicholas, Murie Kathryn, Tukwasibwe Stephen, Wiringilimaana Innocent, Nakasaanyaa Jackie, Mwubaha Caroline, Achom Karen B, Esilu Trevor E, Ayitewalah Alisen, Mbabazi Monica, Kabbale Kisakye D, Mulondo Jerry, Watyekele Eric, Aranda-Diaz Andrés, Maiteki Catherine S, Opigo Jimmy, Dorsey Grant, Nsobya Samuel L, Kamya Moses R, Agaba Bosco B, Ssewanyana Isaac, Greenhouse Bryan, Rosenthal Philip J, Briggs Jessica, Conrad Melissa D

Abstract excerpt

The emergence and spread of drug resistance threaten malaria control in Uganda. This study reports new data on key polymorphisms associated with antimalarial drug sensitivity at 32 malaria reference centers in Uganda in 2023 and 2024. Ten thousand thirty samples were collected from patients aged >6 months presenting with uncomplicated falciparum malaria and sequenced using the MAD4HatTeR panel and Illumina...

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Antimalarials
Artemisinins
Chloroquine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Dihydropteroate Synthase

Malaria, Falciparum

Plasmodium falciparum

Tetrahydrofolate Dehydrogenase

Source

Open in PubMed Open full text

Identifiers

PMID: 42294652
DOI: 10.1128/aac.00361-26
PMCID: PMC13436321

Genes

DHFR
DHPS

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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