Article
Developmental lineage of human pluripotent stem cell-derived cardiac fibroblasts affects their functional phenotype.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2021
Floy Martha E, Givens Sophie E, Matthys Oriane B, Mateyka Taylor D, Kerr Charles M, Steinberg Alexandra B, Silva Ana C, Zhang Jianhua, Mei Ying, Ogle Brenda M, McDevitt Todd C, Kamp Timothy J, Palecek Sean P
Abstract excerpt
Cardiac fibroblasts (CFBs) support heart function by secreting extracellular matrix (ECM) and paracrine factors, respond to stress associated with injury and disease, and therefore are an increasingly important therapeutic target. We describe how developmental lineage of human pluripotent stem cell-derived CFBs, epicardial (EpiC-FB), and second heart field (SHF-FB) impacts transcriptional and functional...
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