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Cardiac differentiation of pluripotent stem cells and implications for modeling the heart in health and disease

4 Apr 2018

Abstract excerpt

Cellular models comprising cardiac cell types derived from human pluripotent stem cells are valuable for studying heart development and disease. We discuss transcriptional differences that define cellular identity in the heart, current methods for generating different cardiomyocyte subtypes, and implications for disease modeling, tissue engineering, and regenerative medicine.

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Identifiers

PMID: 29618562
DOI: 10.1126/scitranslmed.aah5457

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