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Functional cardiac fibroblasts derived from human pluripotent stem cells via second heart field progenitors

20 May 2019

Abstract excerpt

Cardiac fibroblasts (CFs) play critical roles in heart development, homeostasis, and disease. The limited availability of human CFs from native heart impedes investigations of CF biology and their role in disease. Human pluripotent stem cells (hPSCs) provide a highly renewable and genetically defined cell source, but efficient methods to generate CFs from hPSCs have not been described. Here, we show...

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PMID: 31110246
DOI: 10.1038/s41467-019-09831-5

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