Article

Overexpression of ELOVL6 has been associated with poor prognosis in patients with head and neck squamous cell carcinoma

2021-02-14

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) is a high mortality disease. Extension of long-chain fatty acid family member 6 (ELOVL6) is a key enzyme involved in fat formation that catalyzes the elongation of saturated and monounsaturated fatty acids. Overexpression of ELOVL6 has been associated with obesity-related malignancies, including hepatocellular carcinoma, breast, colon, prostate, and pancreatic cancer....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8fa440ff-0edd-5164-a8d1-e999bfeb87e0
DOI: 10.1101/2021.02.13.431065

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Overexpression of ELOVL6 has been associated with poor prognosis in patients with head and neck squamous cell carcinomaDOI 10.1101/2021.02.13.431065Read

Integrative Analysis of Prognostic Value and Immune Infiltration of ELOVL Gene Family in Lung AdenocarcinomaSemantic proximity Read

Identify an Innovative Fatty Acid Metabolism-Related Gene in Head and Neck Squamous Cell CarcinomaSemantic proximity Read

Screening the key genes of prognostic value in the microenvironment for head and neck squamous cell carcinomaSemantic proximity Read

Prognosis and Dissection of the Immune Microenvironment in Head and Neck Squamous Cell Carcinoma Based on Fatty Acid Metabolism-Related SignaturesSemantic proximity Read

CELSR3 is a Prognostic Marker in HNSCC and Correlates with Immune Cell Infiltration in the Tumor MicroenvironmentSemantic proximity Read

The expression of ELOVL4, repressed by MYCN, defines neuroblastoma patients with good outcome.Semantic proximity Read

Low expression of Elovl6 may involve in fat loss in white adipose tissue of cancer-associated cachexiaSemantic proximity Read

Genetic variants in ELOVL2 and HSD17B12 predict melanoma-specific survival.Semantic proximity Read

A comprehensive review of the family of very-long-chain fatty acid elongases: structure, function, and implications in physiology and pathologySemantic proximity Read

Integrated analysis of single cell and spatial transcriptomics revealed a metastasis mechanism mediated by fatty acid metabolism in lymph nodes of head and neck cancerSemantic proximity Read

ALOX15 may function as a tumor biomarker, transitioning from pan-cancer comprehensive analysis to validation within head and heck squamous cell carcinomaSemantic proximity Read

Peroxisome proliferator-activated receptors signature reveal the head and neck squamous cell carcinoma energy metabolism phenotype and clinical outcome.Semantic proximity Read