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Article

Correlation of Electrophysiological and Fluorescence-Based Measurements of Modulator Efficacy in Nasal Epithelial Cultures Derived from People with Cystic Fibrosis.

Cells - 17 Apr 2023

Gunawardena Tarini N A, Bozóky Zoltán, Bartlett Claire, Ouyang Hong, Eckford Paul D W, Moraes Theo J, Ratjen Felix, Gonska Tanja, Bear Christine E

Abstract excerpt

It has been suggested that in vitro studies of the rescue effect of CFTR modulator drugs in nasal epithelial cultures derived from people with cystic fibrosis have the potential to predict clinical responses to the same drugs. Hence, there is an interest in evaluating different methods for measuring in vitro modulator responses in patient-derived nasal cultures. Commonly, the functional response to CFTR modulator...

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PMID: 37190083
DOI: 10.3390/cells12081174
PMCID: PMC10136647

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