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WNT inhibitor SP5-mediated SERPING1 suppresses lung adenocarcinoma progression via TSC2/mTOR pathway

17 Feb 2025

Abstract excerpt

The long-term outlook for patients grappling with lung cancer (LC) remains bleak, with lung adenocarcinoma (LUAD) emerging as the most predominant histological subtype. Our Mendelian randomization (MR) investigation spotlighted that heightened levels of the circulating protein serpin peptidase inhibitor family G1 (SERPING1) substantially mitigated LC risk. The fusion of multi-omics strategies unveiled that...

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Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Share to PI3K/AKT/mTOR signaling in cancer
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PMID: 39962118
DOI: 10.1038/s41419-025-07440-3

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