Article
Significance of BRCA2 and RB1 Co-loss in Aggressive Prostate Cancer Progression.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2020
Chakraborty Goutam, Armenia Joshua, Mazzu Ying Z, Nandakumar Subhiksha, Stopsack Konrad H, Atiq Mohammad O, Komura Kazumasa, Jehane Lina, Hirani Rahim, Chadalavada Kalyani, Yoshikawa Yuki, Khan Nabeela A, Chen Yu, Abida Wassim, Mucci Lorelei A, Lee Gwo-Shu Mary, Nanjangud Gouri J, Kantoff Philip W
Abstract excerpt
PURPOSE: Previous sequencing studies revealed that alterations of genes associated with DNA damage response (DDR) are enriched in men with metastatic castration-resistant prostate cancer (mCRPC). BRCA2, a DDR and cancer susceptibility gene, is frequently deleted (homozygous and heterozygous) in men with aggressive prostate cancer. Here we show that patients with prostate cancer who have lost a copy of BRCA2...
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