Article
GRAMM: A new method for analysis of HLA in families.
HLA - 1 Oct 2023
Ansbacher-Feldman Zuriya, Israeli Sapir, Maiers Martin, Gragert Loren, De Santis Dianne, Israeli Moshe, Louzoun Yoram
Abstract excerpt
Recently, haplo-identical transplantation with multiple HLA mismatches has become a viable option for stem cell transplants. Haplotype sharing detection requires the imputation of donor and recipient. We show that even in high-resolution typing when all alleles are known, there is a 15% error rate in haplotype phasing, and even more in low-resolution typings. Similarly, in related donors, the parents' haplotypes...
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