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Article

Upregulation of Glutamic-Oxaloacetic Transaminase 1 Predicts Poor Prognosis in Acute Myeloid Leukemia

24 Mar 2020

Abstract excerpt

One of the key features of acute myeloid leukemia (AML), a group of very aggressive myeloid malignancies, is their strikingly heterogenous outcomes. Accurate biomarkers are needed to improve prognostic assessment. Glutamate oxaloacetate transaminase 1 (GOT1) is essential for cell proliferation and apoptosis by regulating cell’s metabolic dependency on glucose. It is unclear whether the expression level of GOT1...

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PMID: 32266153
DOI: 10.3389/fonc.2020.00379

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