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Risk-reducing salpingo-oophorectomy and breast cancer incidence among Jewish BRCA1/BRCA2-mutation carriers-an Israeli matched-pair study.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics - 1 May 2022

Perri Tamar, Levin Gabriel, Naor-Revel Shani, Eliassi-Revivo Perry, Lifshitz Dror, Friedman Eitan, Korach Jacob

Abstract excerpt

OBJECTIVE: To study the association of risk-reducing bilateral salpingo-oophorectomy (RRBSO) and breast cancer risk among BRCA pathogenic sequence variants (PSV). METHODS: Jewish Israeli BRCA carriers who underwent RRBSO were matched with those who did not-by the mutated gene and year of birth (±1 year). Breast cancer rates were compared. RESULTS: Overall, 127 pairs met the inclusion criteria, 79 (60.6%) pairs...

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PMID: 34324701
DOI: 10.1002/ijgo.13843

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