Breast and ovarian cancer risk and risk reduction in Jewish BRCA1/2 mutation carriers.

doi:10.1200/JCO.2011.37.8133

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Breast and ovarian cancer risk and risk reduction in Jewish BRCA1/2 mutation carriers.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Apr 2012

Finkelman Brian S, Rubinstein Wendy S, Friedman Sue, Friebel Tara M, Dubitsky Shera, Schonberger Niecee Singer, Shoretz Rochelle, Singer Christian F, Blum Joanne L, Tung Nadine, Olopade Olufunmilayo I, Weitzel Jeffrey N, Lynch Henry T, Snyder Carrie, Garber Judy E, Schildkraut Joellen, Daly Mary B, Isaacs Claudine, Pichert Gabrielle, Neuhausen Susan L, Couch Fergus J, van't Veer Laura, Eeles Rosalind, Bancroft Elizabeth, Evans D Gareth, Ganz Patricia A, Tomlinson Gail E, Narod Steven A, Matloff Ellen, Domchek Susan, Rebbeck Timothy R

Abstract excerpt

PURPOSE: Mutations in BRCA1/2 dramatically increase the risk of both breast and ovarian cancers. Three mutations in these genes (185delAG, 5382insC, and 6174delT) occur at high frequency in Ashkenazi Jews. We evaluated how these common Jewish mutations (CJMs) affect cancer risks and risk reduction. METHODS: Our cohort comprised 4,649 women with disease-associated BRCA1/2 mutations from 22 centers in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Risk Reduction Behavior

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Age Distribution

Share to Confidence Intervals

Share to Genes, BRCA1

Share to Genes, BRCA2

Share to Germ-Line Mutation

Share to Jews

Share to Proportional Hazards Models

Source

Open in PubMed Open full text

Identifiers

PMID: 22430266
DOI: 10.1200/JCO.2011.37.8133
PMCID: PMC3341145

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Breast and ovarian cancer risk and risk reduction in Jewish BRCA1/2 mutation carriers.PMID 22430266Read ↗

Prevalence and penetrance of BRCA1 and BRCA2 gene mutations in unselected Ashkenazi Jewish women with breast cancer.Semantic proximity Read ↗

Risk-reducing salpingo-oophorectomy and breast cancer incidence among Jewish BRCA1/BRCA2-mutation carriers-an Israeli matched-pair study.Semantic proximity Read ↗

Ovarian cancer risk in Ashkenazi Jewish carriers of BRCA1 and BRCA2 mutations.Semantic proximity Read ↗

Incidence of BRCA1 and BRCA2 non-founder mutations in patients of Ashkenazi Jewish ancestry.Semantic proximity Read ↗

Hereditary breast cancer in Jews.Semantic proximity Read ↗

Prevalence and predictors of BRCA1 and BRCA2 mutations in a population-based study of breast cancer in white and black American women ages 35 to 64 years.Semantic proximity Read ↗

Hereditary breast and ovarian cancer due to mutations in BRCA1 and BRCA2.Semantic proximity Read ↗

The risks of breast and ovarian cancer associated with the Ashkenazi Jewish founder allele BRCA2 6174delT.Semantic proximity Read ↗

Identifying Ashkenazi Jewish <i>BRCA1/2</i> founder variants in individuals who do not self-report Jewish ancestrySemantic proximity Read ↗

A population-based study of BRCA1 and BRCA2 mutations in Jewish women with epithelial ovarian cancer.Semantic proximity Read ↗

Genetic Predisposition to Breast Cancer Due to Mutations Other Than BRCA1 and BRCA2 Founder Alleles Among Ashkenazi Jewish Women.Semantic proximity Read ↗

Identifying Ashkenazi Jewish BRCA1/2 founder variants in individuals who do not self-report Jewish ancestry.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.