Article
Unique TP53 neoantigen and the immune microenvironment in long-term survivors of Hepatocellular carcinoma.
Cancer immunology, immunotherapy : CII - 1 Mar 2021
Yang Huayu, Sun Lejia, Guan Ai, Yin Huanhuan, Liu Meixi, Mao Xinxin, Xu Haifeng, Zhao Haitao, Lu Xin, Sang Xinting, Zhong Shouxian, Chen Qian, Mao Yilei
Abstract excerpt
Neoantigens are T-cell antigens derived from protein-coding mutations in tumor cells. Although neoantigens have recently been linked to anti-tumor immunity in long-term survivors of cancers such as melanoma, their prognostic and immune-modulatory role in many cancer types remain unexplored. We investigate neoantigens in hepatocellular carcinoma (HCC) through a combination of whole exome sequencing (WES), RNA...
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